How much weight can I lose on semaglutide?

The STEP-1 Phase 3 trial showed an average 14.9% body weight reduction at 2.4mg semaglutide over 68 weeks. Individual results vary — some lose more, some less. This is the population average from a controlled trial.

How does tirzepatide compare to semaglutide for weight loss?

Tirzepatide showed approximately 20.9% body weight reduction in the SURMOUNT-1 trial at 15mg dose, compared to 14.9% for semaglutide. This difference is statistically significant and clinically meaningful. Tirzepatide's GIP+GLP-1 dual agonism appears to drive greater weight loss.

What is the maximum weight loss on retatrutide?

Phase 2 trials showed up to 24.2% body weight reduction at 12mg retatrutide over 48 weeks. This is the highest reported weight loss of any pharmacotherapy at the time of publication. Phase 3 TRIUMPH results are pending.

Based on Phase 3 Clinical Trial Data

🧬 GLP-1 Weight Loss Plotter

Enter your weight and goal. See projected timeline based on real clinical trial averages — not marketing claims.

Current Weight (lbs)

Goal Weight (lbs)

Select GLP-1 Drug

Semaglutide

14.9%

Wegovy 2.4mg (STEP-1)

Tirzepatide

20.9%

Zepbound 15mg (SURMOUNT-1)

Retatrutide

24.2%

12mg Phase 2 (Not FDA approved)

Your Projected Timeline

⚠️ These are population averages, not guarantees. Individual results vary significantly. Some people lose more, some less. Weight loss also slows over time and plateaus are common. Maintenance requires sustained treatment and lifestyle changes. Consult a physician before starting any GLP-1 drug.

📊 Clinical Trial Data Behind This Tool

Weight loss percentages are from published Phase 2/3 trial primary endpoints. Not extrapolated or adjusted.

Drug	Trial	Dose	Duration	Avg Loss	Source
Semaglutide	STEP-1	2.4mg/wk SC	68 weeks	14.9%	NEJM 2021
Tirzepatide	SURMOUNT-1	15mg/wk SC	72 weeks	20.9%	NEJM 2022
Retatrutide	Phase 2	12mg/wk SC	48 weeks	24.2%	NEJM 2023

📊

Tirzepatide Results

Full SURMOUNT trial data visualized

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🚀

Retatrutide Results

Phase 2 data — the highest numbers ever

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💊

Established GLP-1 Drugs

Liraglutide, dulaglutide, semaglutide compared

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❓

Semaglutide Not Working?

8 reasons why and what to do

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Key Takeaways

✅ What We Know

Tirzepatide (20.9%) outperforms semaglutide (14.9%) in head-to-head trials
Retatrutide (24.2%) is the strongest in development
Phase 3 trial data is the most reliable benchmark

⚠️ What We Don't Know

Individual response varies substantially from trial averages
Long-term maintenance data is still emerging
Phase 3 TRIUMPH results for retatrutide are pending

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🛒 Weight Loss Tracking Tools

Tools to track your GLP-1 journey — body composition, food logging, and measurement tracking.

⚖️ Smart Scale Body composition tracking with app sync 📏 Body Measuring Tape Track waist, chest, and limb measurements 🍱 Meal Prep Containers Portion control for GLP-1 nutrition ⚖️ Food Scale Precise calorie and macro tracking

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⚕️ Disclaimer

This page is for educational and informational purposes only. It is not medical advice. Always consult a qualified healthcare provider before starting any supplement or medication. HighPeptides may receive affiliate compensation from linked vendors.