Russian Anxiolytic • GABA Modulator

Selank: The Anxiolytic Peptide

By , HighPeptides Editor

Last updated: March 2026

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed at Russia's Institute of Molecular Genetics. It modulates GABA receptor function with anxiolytic effects comparable to benzodiazepines — without the sedation, cognitive impairment, or dependence risk.

0
Amino Acid
Heptapeptide
GABA
Primary
Target System
🇷🇺
Approved in
Russia
📋 On this page
  1. What Is Selank?
  2. What the Research Shows
  3. Side Effects & Safety Profile
  4. Study Citations
  5. Who Researches Selank?
  6. Key Takeaways
  7. 🔬 Verified Research Source
  8. Related Resources
Background

What Is Selank?

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a modified tuftsin analog with a Pro-Gly-Pro tripeptide extension that stabilizes it against enzymatic degradation. It was developed for treating generalized anxiety disorder and neurasthenia.

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GABAA Receptor Modulation

Allosterically modulates GABAA receptors, altering the expression of genes involved in GABAergic neurotransmission — including GABRA2, GABRA6, and GABRB2 subunit genes.

🧠
Monoamine Modulation

Influences serotonin, dopamine, and norepinephrine metabolism. Stabilizes enkephalin degradation, extending the activity of endogenous opioid peptides.

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Immunomodulation

Derived from tuftsin, retains immunomodulatory properties. Influences IL-6 and interferon expression, bridging the neuro-immune axis.

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BDNF Expression

Increases brain-derived neurotrophic factor expression, providing potential neuroprotective effects alongside its anxiolytic action.

Research

What the Research Shows

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Context: Selank was approved in Russia in 2009 for anxiety and neurasthenia. Clinical data predominantly comes from Russian institutions. The anxiolytic effects are well-documented, but Western clinical data is limited.

Generalized Anxiety Disorder — Russian Clinical Studies
Anxiolytic effect comparable to diazepam without sedation or dependence
Positive
GABAergic Gene Expression — Molecular Studies
Selank altered expression of GABA receptor subunit genes in neuroblastoma cells
Positive
Diazepam Enhancement — Chronic Stress Model
Enhanced anxiolytic effects of diazepam in unpredictable chronic mild stress in rats
Positive
Cognitive Function
Improved attention and memory in patients with anxiety — unlike benzodiazepines
Positive
Safety

Side Effects & Safety Profile

Nasal Irritation
Mild irritation at intranasal administration site
Mild
Sedation / Cognitive Impairment
Not reported — key advantage over benzodiazepines
—
Dependence / Withdrawal
No dependence or withdrawal effects reported in clinical use
—
Sources

Study Citations

Gene Expression
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells
Frontiers in Pharmacology, 2017 · doi: 10.3389/fphar.2017.00089
Gene Expression
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
Frontiers in Pharmacology, 2016 · PMC4757669
Combination Study
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
Behavioural Neurology, 2017 · PMC5322660

Self-Assessment

Who Researches Selank?

This Research Is Commonly Explored By People Who...

  • Are interested in anxiolytic alternatives without benzodiazepine dependence risk
  • Want to understand GABAergic modulation via peptide-based approaches
  • Are exploring the intersection of immune modulation and anxiety
  • Are interested in Russian-developed nootropic/anxiolytic peptides

This Research May Not Be Relevant If...

  • You want FDA-approved anxiety treatments — Selank is not available in the US
  • You prefer oral medications — Selank requires intranasal administration
  • You want extensive Western clinical trial data — most data is from Russian institutions
📚

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Bottom Line

Key Takeaways

✅ What We Know
  • Anxiolytic effects comparable to benzodiazepines
  • No sedation, cognitive impairment, or dependence
  • Modulates GABAA receptor gene expression
  • Approved in Russia since 2009
  • Also has immunomodulatory properties
⚠️ What We Don't Know
  • Not FDA approved — no Western clinical trials
  • Limited long-term safety data
  • Exact binding mechanism still under investigation
  • Requires intranasal administration (no oral form)

🔬 Verified Research Source

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Research Supplies

Tools and supplies relevant to this research area.

🧴 Empty Nasal Spray Bottles 10mL plastic spray bottles for compounding intranasal peptide solutions. 💧 Distilled Water Lab-grade distilled water for dissolving water-soluble peptides. 📏 pH Test Strips Verify final solution pH (target ~5–7 for nasal peptides). ❄️ Mini Fridge for Peptides Keep reconstituted peptides at 2–8°C between doses.

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⚠️ Disclaimer

Selank is NOT FDA approved in the United States. It is approved in Russia for anxiety and neurasthenia. This page is for educational purposes only. Not medical advice. Approved Russia Not Available US