Compounds & Guides
5-Amino-1MQ5-Amino-1MQ research guide: NNMT inhibition, fat loss mechanism, metabolic effects, dosing protocol, and evidence…
AdipotideAdipotide research: peptidomimetic targeting adipose vasculature. ~11% weight loss in primates. Research-only compound,…
BerberineBerberine activates AMPK like metformin, lowering HbA1c 0.5–0.9%, LDL 20–25%, and triglycerides 25–35%. Dosing, DHB,…
Best Peptides for Weight LossComplete comparison of weight loss peptides ranked by evidence: semaglutide, tirzepatide, retatrutide, tesamorelin,…
Cagrilintide & CagriSemaCagrilintide is a long-acting amylin analog. With semaglutide as CagriSema it produced 20.4% weight loss in REDEFINE 1.…
CagriSemaCagriSema is Novo Nordisk's once-weekly cagrilintide + semaglutide combo for obesity. Phase 3 REDEFINE trials, dosing,…
Compounded SemaglutideFDA shortage resolved Feb 2025, telehealth crackdown, Hims/Hers DOJ probe, Novo lawsuit. Where compounded semaglutide…
CotadutideCotadutide (MEDI0382): a daily GLP-1/glucagon dual agonist. How its two-receptor mechanism drives weight loss and…
DanuglipronDanuglipron was Pfizer's oral GLP-1 pill. Discontinued April 2025 over a drug-induced liver injury signal. Timeline,…
EcnoglutideEcnoglutide (XW003) is a cAMP-biased GLP-1 receptor agonist from Sciwind. Phase 3 obesity data, lower receptor…
ExenatideExenatide (Byetta, Bydureon) was the first GLP-1 receptor agonist — a 39-amino-acid peptide from Gila monster venom.…
GLP-1 and AlcoholGLP-1 agonists like semaglutide reduce alcohol intake — JAMA Psychiatry phase 2 (50% craving reduction) and 83K-patient…
GLP-1 and Bone DensityGLP-1 bone density risk: -1% annualized hip BMD loss in non-diabetics on sema/tirz, tirzepatide HR 1.44 for…
Liraglutide & DulaglutideLiraglutide vs Dulaglutide: daily vs weekly GLP-1. SCALE & REWIND data on weight loss and CV benefit.
GLP-1 Agonists & Insulin ResistanceGLP-1 agonists beyond appetite: direct effects on insulin resistance, beta cell protection, and neurological benefits…
Intermittent Fasting on GLP-1sEvidence-based review of intermittent fasting with GLP-1 agonists (semaglutide, tirzepatide). Honest risks and what the…
GLP-1 Muscle Loss25-40% of GLP-1 weight loss is muscle. Evidence-based strategies to preserve lean mass on semaglutide or tirzepatide.
GLP-1 PipelineThe 5 most promising GLP-1 pipeline drugs: orforglipron, cagrisema, survodutide, pemvidutide, mazdutide. 20%+ weight…
GLP-1 and Thyroid CancerGLP-1 thyroid warning: rodent C-cell tumor data, human evidence, MTC contraindication, Mayo Clinic detection-bias data.
How to Get Retatrutide inRetatrutide sourcing guide: Phase 3 TRIUMPH-1 published (−25.0% at 12 mg, 80 wk), not yet FDA-approved. Legal status,…
L-Carnitine InjectableInjectable L-carnitine bypasses poor oral bioavailability. Transports fatty acids into mitochondria, upregulates…
LiraglutideLiraglutide (Saxenda, Victoza) is a once-daily GLP-1 receptor agonist. SCALE Obesity trial data, dosing, mechanism, and…
MazdutideMazdutide (IBI362) is a GLP-1/glucagon dual agonist from Innovent. GLORY-1 NEJM data, GLORY-2 ≥18% weight loss, Chinese…
Metabolic AdaptationAdaptive thermogenesis traps chronic dieters under 2,000 kcal. Retatrutide's glucagon arm may raise the metabolic…
Metformin for LongevityMetformin longevity research: AMPK activator, TAME trial, reduced all-cause mortality. Exercise blunting controversy…
Myo-InositolMyo-inositol research — 2g BID protocol for PCOS and fertility. Evidence from controlled trials, insulin sensitivity…
Myostatin InhibitorsBimagrumab, Trevogrumab, Apitegromab — the antibody class targeting muscle wasting. Clinical data + where they fit with…
Natural Metformin AlternativesThe complete natural metformin alternative stack — berberine, curcumin, cinnamon, ACV, and inositol. Protocols, dosing,…
OrforglipronOrforglipron (Foundayo) is the first oral non-peptide GLP-1 pill. FDA-approved April 2026 by Lilly. Mechanism, trial…
Ozempic AlternativesOzempic alternatives for 2026: compare tirzepatide, retatrutide, compounded semaglutide, oral GLP-1s, and natural…
Ozempic FaceOzempic face explained: rapid GLP-1 weight loss causes facial fat pad shrinkage, collagen loss, and skin laxity.…
Ozempic MicrodosingOzempic microdosing: 0.05–0.25 mg semaglutide protocols for metabolic flexibility, longevity, and side-effect…
Retatrutide Before and AfterRetatrutide before and after: 25.0% mean weight loss at 80 weeks in Phase 3 TRIUMPH-1 (24.2% at 48wk in Phase 2). By…
RetatrutideRetatrutide is more than a weight-loss drug. GLP-1 / GIP / glucagon agonism affects brain, bone, testosterone, and…
RetatrutideWhat retatrutide's trials show beyond weight loss: lipids, blood pressure and glycemic control, plus the Phase 3…
Retatrutide vs SemaglutideTRIUMPH-1 (NEJM 2026): retatrutide −25.0% at 12 mg over 80 weeks. STEP 1: semaglutide −14.9% at 68 weeks. Separate…
Retatrutide Clinical Trial ResultsRetatrutide (LY3437943): Phase 3 TRIUMPH-1 reported a mean 25.0% weight loss on 12 mg at 80 weeks (NEJM 2026); Phase 2…
Retatrutide Side EffectsRetatrutide side effects from the Phase 2 trial (NEJM 2023, N=338): GI rates by dose, severity, 6-16% discontinuation.…
Semaglutide and Cartilage RepairA 24-week pilot (n=20) reported ~17% cartilage thickness gain with semaglutide plus hyaluronic acid. The…
Semaglutide Not Working? 8 Reasons WhySemaglutide not working? 8 evidence-based reasons why — from dosing issues to metabolic adaptation — and what to do…
Semaglutide Research ResultsVisual breakdown of semaglutide (Wegovy/Ozempic) STEP 1 trial data. 14.9% average weight loss over 68 weeks. Compare vs…
SetmelanotideFirst FDA-approved MC4R agonist for rare genetic obesity (POMC, LEPR, BBS). Mechanism, Phase 3 trial data, dosing, and…
SurvodutideSurvodutide (BI 456906) is a GLP-1/glucagon dual agonist. 19% weight loss and 83% MASH improvement in Phase 2. FDA…
TesofensineTesofensine research — triple monoamine reuptake inhibitor showing ~10% body weight loss in Phase 3 trials. 0.5-1mg…
Tirzepatide Weight Loss ResultsTirzepatide (Mounjaro/Zepbound) weight loss results from SURMOUNT trials. 20.9% body weight reduction. Dual GIP/GLP-1…
Tirzepatide vs SemaglutideTirzepatide vs semaglutide compared: dual GIP/GLP-1 vs GLP-1 only. SURMOUNT vs STEP trial data on weight loss and side…
Wegovy vs ZepboundWegovy vs Zepbound 2026: Zepbound 20% vs Wegovy 14% mean weight loss. Wegovy 7.2 mg new dose. Cost, insurance, side…
YohimbineYohimbine blocks alpha-2 receptors to boost norepinephrine and mobilize stubborn fat when fasted. Also used for ED.…
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Educational purposes only. Not medical advice. The compounds listed here are research chemicals or prescription medications discussed for informational purposes. Nothing on this page is a recommendation to use any substance. Consult a licensed healthcare provider.