⚠️ Harm Reduction Resource — Not Medical Advice. This chart is for educational purposes only. Always consult a healthcare professional. Never combine substances without thorough research. When in doubt, don't.
Substance Combination Chart
Last updated: March 2026
Interactive safety matrix based on TripSit’s harm-reduction combination data. Click any cell for details.
Low Risk + Synergy
Low Risk + Decrease
Caution
Unsafe
Dangerous
Unknown
How to Use This Chart
Reading the Grid
Find one substance on the top row and the other on the left column. The cell where they intersect shows the safety profile of that combination.
Data Sources
Based on TripSit combo chart data, published research, and established harm reduction knowledge. Individual responses may vary significantly.
Key Dangers
MAOIs with serotonergic drugs (serotonin syndrome), Lithium with psychedelics (seizures), and respiratory depressant combos (alcohol + opioids) are the most critical risks.
Set & Setting
Even "low risk" combinations can be overwhelming. Dose, set, setting, and individual physiology all matter. Start low and go slow.