AOD-9604: The Fat Loss Fragment
Last updated: March 2026
AOD-9604 is a synthetic peptide corresponding to amino acids 177–191 of human growth hormone — the C-terminal fragment responsible for fat metabolism. Unlike full HGH, it stimulates lipolysis and inhibits lipogenesis without affecting IGF-1 levels or blood glucose. Research dosing is typically 500 mcg via subcutaneous injection. Approved as a supplement by Australia's TGA; not FDA-approved.
(typical/day)
Acids
(Australia)
What Is AOD-9604?
AOD-9604 is a synthetic peptide corresponding to amino acids 177-191 of the growth hormone sequence — the C-terminal fragment responsible for fat metabolism, isolated from the growth-promoting effects.
AOD-9604 directly stimulates the breakdown of stored fat (lipolysis) in adipose tissue, promoting fat loss without affecting lean muscle.
Unlike full HGH, AOD-9604 does not affect IGF-1 levels or blood glucose. This avoids the metabolic side effects associated with growth hormone.
AOD-9604 also inhibits the creation of new fat cells (lipogenesis), helping prevent fat accumulation during use.
Administered via subcutaneous injection. The peptide is stable and has a good safety profile in research models.
What the Research Shows
Research data on AOD-9604's fat loss mechanism.
Key Takeaways
- HGH fragment (amino acids 177-191)
- Stimulates lipolysis directly
- Does not affect IGF-1 or blood glucose
- Approved as supplement in Australia (TGA)
- No growth effects like full HGH
- Limited human clinical trial data
- Not FDA approved in US
- Optimal dosing protocols not established
- Long-term safety unknown
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This page is for educational purposes only. AOD-9604 is not FDA approved. TGA approval is for Australia only. Always consult a healthcare provider.
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