RAD-140 (Testolone): The Highest Potency SARM
Last updated: March 2026
90:1 anabolic to androgenic ratio — the strongest selectivity of any SARM. Investigated by Radius Health for breast cancer. Neuroprotective in preclinical models. Here's the research.
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📋 On this page
How RAD-140 Works
Highest anabolic:androgenic ratio of any SARM. Powerful muscle-building with fewer androgenic side effects.
~90:1 selectivity vs testosterone's 1:1. Strong anabolic effects with minimized prostate/hair/skin androgenic activity. Investigated for women's breast cancer to avoid masculinizing side effects.
Preclinical studies show protection against kainic acid seizures and 6-OHDA lesioning. Reduced brain damage in rodent models via AR-mediated anti-apoptotic signaling. Human data: none.
Radius Health investigated RAD1901 (metabolite) for ER+/AR+ breast cancer. The rationale: AR expression in these cancers, selective activation could slow growth. Phase 2 reached, licensed to Novartis.
High AR affinity = significant HPG axis suppression. At 10-20mg research doses, testosterone drops 50%+. Among the more suppressive SARMs. Recovery: 4-8 weeks. PCT recommended.
What the Research Shows
Data context: Most efficacy data from rodent studies. Human muscle-building data at research doses is anecdotal extrapolated from animal models.
Side Effects & Risks
- Strong testosterone suppression (50%+ at research doses)
- Significant LH/FSH reduction
- Liver enzyme elevation (ALT/AST)
- Long half-life = slow washout
- PCT commonly recommended
- HDL cholesterol reduction
- Lipid profile changes
- Headaches reported
- Water retention possible
- Acne in some users
Study Citations
🎯 Who Is This For?
✅ Good Candidate If You...
- • Want the strongest anabolic SARM available for lean mass research
- • Are interested in body recomposition — building muscle while reducing fat
- • Understand the need for PCT and blood work monitoring
- • Have experience with SARMs or performance compounds and understand the risks
❌ Not Ideal If You...
- • Are a beginner to performance compounds — RAD-140 is one of the most suppressive SARMs
- • Have liver concerns — RAD-140 elevates liver enzymes (ALT/AST) at research doses
- • Want to maintain fertility — significant testosterone and LH/FSH suppression occurs
- • Are pregnant, breastfeeding, or under 25 — hormonal disruption risk is high
- • Compete in WADA-tested sports — all SARMs are banned substances
⚕️ Always consult a healthcare provider before starting any peptide protocol.
Key Takeaways
- Highest anabolic:androgenic ratio (~90:1) of any SARM
- Preclinical neuroprotection data in rodents
- Investigated for ER+/AR+ breast cancer
- More potent than Ostarine/LGD-4033 mg-for-mg
- 16-hour half-life allows daily dosing
- Human muscle-building data at research doses
- Long-term liver toxicity at 10-20mg
- Recovery timeline without PCT
- Quality of research chemical supply
- Cardiovascular effects long-term
🔬 Verified Research Source
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Educational only. Not medical advice. RAD-140 is NOT FDA approved. Banned by WADA. Consult healthcare provider. HighPeptides does not sell SARMs.