Anti-Dementia & Neuroprotection Stack
A ten-compound protocol targeting four convergent pathways: cholinergic support, mitochondrial function, nerve growth, and oxidative stress. Built for long-arc cognitive resilience, not acute performance.
What's in the Stack
Alpha-GPC, CDP-Choline, and Lion's Mane supply acetylcholine precursors and encourage NGF. Acetylcholine is the first neurotransmitter system to fail in Alzheimer's.
CoQ10, Methylene Blue, and Omega-3 DHA support cytochrome-c oxidase and membrane fluidity. Neurons have the highest mitochondrial density of any cell type.
NAC is a glutathione precursor; Bacopa adds saponin antioxidants. Oxidative stress drives amyloid and tau accumulation.
Bromantane and Benfotiamine (fat-soluble B1) address HPA axis and AGE accumulation — both mechanisms implicated in cognitive decline.
Daily Dosing Schedule
What to Expect — and When
Key Takeaways
- Targeting 4 convergent pathways is mechanistically stronger than any single compound
- All 10 compounds have human safety data and are available OTC
- Lion's Mane + cholinergic support has the most consistent cognitive-benefit data
- Benfotiamine reaches brain tissue better than water-soluble thiamine
- Total monthly cost ~$127 USD at standard supplement retail prices
- No RCT has tested this specific 10-compound combination end-to-end
- Individual response varies — some compounds may not add marginal benefit for you
- Methylene blue can interact with SSRIs (serotonin syndrome risk); check your stack
- Bromantane is a Russian research compound with less Western safety data
- Dementia prevention endpoints are decades away — we're proxying via biomarkers
Frequently Asked Questions
How soon will I feel effects?
Mitochondrial compounds (CoQ10, methylene blue) within 1–2 weeks. Acetylcholine precursors and Lion's Mane at 4–8 weeks. Bacopa requires a full 12 weeks. Structural benefits of benfotiamine AGE reduction take months.
Which compound has the strongest evidence?
Lion's Mane for NGF/BDNF has the most consistent human cognitive data in the stack. Omega-3 DHA is second (decades of dementia-prevention epidemiology).
Can I drop compounds to cut cost?
Yes — if budget is the limit, keep Omega-3, Lion's Mane, CDP-Choline, NAC, and Benfotiamine. That covers 3 of the 4 pathways at ~$70/month.
Any compounds to avoid with common medications?
Methylene blue + SSRIs can trigger serotonin syndrome. NAC may reduce blood clotting if you're on anticoagulants. Talk to your doctor if you take any prescription medication.
🛒 Recommended Products
Support supplements and gear relevant to this protocol.
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47-page guide: protocols, dosing, sourcing — everything in one place.
Get the guide — $19 (normally $29) → New to peptides? Start with the $19 Buyer’s Playbook → All ebooks & guides →This is an educational overview of a long-arc neuroprotection stack, not a medical recommendation. None of the compounds listed are FDA-approved for dementia prevention or treatment.
Always consult a qualified healthcare provider before starting any supplement protocol — especially if you take prescription medication (SSRI, anticoagulant, or metabolic drugs warrant particular care).
Dosing ranges reflect common protocols in user communities and the published literature; individual needs vary.
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