Growth-hormone secretagogues, SARMs, and myostatin inhibitors — the peptide toolkit for body composition. Real mechanisms, honest evidence ratings, and stack-appropriate dosing.
Compounds with the strongest trial data. Each card links to the full research deep-dive.
The most-used GH combo. CJC-1295 (GHRH analog, long-acting) stimulates hypothalamic release. Ipamorelin (selective GHSR agonist) triggers pituitary release. Pulsatile GH elevation without cortisol/prolactin spike.
~7.5x peak GH elevation. More potent than GHRP-6 for GH release with less appetite stimulation. Hexapeptide ghrelin mimetic.
GHRH analog with FDA approval for HIV-associated lipodystrophy. Reduces visceral fat while preserving lean mass. The GHRH peptide with the best clinical data.
Blocks myostatin — the protein that limits muscle growth. Preclinical evidence is strong; human data remains limited. One of the most promising frontier muscle-growth compounds.
PPARδ agonist — exercise mimetic. Increases endurance and fat oxidation in animal studies. Banned by WADA; human data limited. Used in cutting contexts.
Selective androgen receptor modulator targeting muscle + bone. Better side-effect profile than traditional anabolics. Still not FDA-approved; research-use only.
The GH pathway combo. Long-acting GHRH + selective GHSR triggers pulsatile GH release without the downsides of injected rhGH.
Read more →BPC-157 + TB-500 pair with muscle-growth protocols to preserve joint integrity during heavy training phases.
Read more →Supporting stack for training intensity: CoQ10 ubiquinol, PQQ, D-ribose, creatine. Improves ATP turnover and recovery.
Read more →Without DAC is pulsatile — matches natural GH release. With DAC has a longer half-life but creates sustained elevation that may blunt the pulsatile pattern. Most performance protocols use "without DAC" (CJC-1295 Mod GRF 1-29) paired with Ipamorelin.
Mechanistically yes — they rely on your pituitary's own regulation, so you can't "overdose" on GH the way you can with exogenous rhGH. Downsides: less potent than rhGH, and long-term tolerance may develop.
SARMs have better tissue selectivity and less impact on prostate/hair/skin than traditional anabolics. They still affect lipids, liver enzymes, and HPTA (hypothalamic-pituitary-testicular axis). They're not safe — just safer.
Research-use only. Most are not FDA-approved for human use. SARMs are in a gray zone — legal to possess, not legal to sell as supplements. Ostarine is banned by WADA and most sports federations.
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16 related research pages covering specific questions, compounds, and edge cases.
Most compounds on this page are research-use only and not FDA-approved for muscle growth. SARMs, GH peptides, and myostatin inhibitors all carry specific risk profiles.
Not medical advice. Athletes: most compounds here are banned by WADA and sport federations. Research use only.